LACTEL Absorbable Polymers.
Chemical Properties of Select Polymers
| Polymer | Inherent Viscosity (dL/g) |
Crystalline Melt Transition (°C) |
Glass Transition Temp (°C) |
Solubility (at 5% w/w) |
Approx. Resorption (months) |
|---|---|---|---|---|---|
| · Solvents (partial listing only)
1 = dichloromethane 2 = tetrahydrofuran 3 = ethyl acetate 4 = chloroform 5 = hexafluoroisopropanol 6 = acetone |
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| 50:50 DL-PLG | 0.55 - 0.75 | Amorphous | 45 - 50 | 1 2 3 4 5 6 | 1 - 2 |
| 65:35 DL-PLG | 0.55 - 0.75 | Amorphous | 45 - 50 | 1 2 3 4 5 6 | 3 - 4 |
| 75:25 DL-PLG | 0.55 - 0.75 | Amorphous | 50 - 55 | 1 2 3 4 5 6 | 4 - 5 |
| 85:15 DL-PLG | 0.55 - 0.75 | Amorphous | 50 - 55 | 1 2 3 4 5 6 | 5 - 6 |
| DL-PLA | 0.55 - 0.75 | Amorphous | 50 - 60 | 1 2 3 4 5 6 | 12 - 16 |
| L-PLA | 0.90 - 1.20 | 173 - 178 | 60 - 65 | 1 4 5 | >24 |
| PGA | 1.40 - 1.80 | 225 - 230 | 35 - 40 | 5 | 6 - 12 |
| PCL | 1.00 - 1.30 | 58-63 | (-65) - (-60) | 1 4 5 | >24 |
| 25:75 DL-PLCL | 0.70 - 0.90 | Amorphous | (-50) - (-40) | 1 4 5 | |
| 80:20 DL-PLCL | 0.70 - 0.90 | Amorphous | 17 - 23 | 1 4 5 | |
Physical Properties of Select Polymers
| Polymer | Specific Gravity (g/mL) |
Tensile Strength (psi) |
Elongation (%) | Modulus (psi) |
|---|---|---|---|---|
| DL-PLG = poly(DL-lactide-co-glycolide) DL-PLA = poly(DL-lactide) L-PLA = poly(L-lactide) PGA = poly(glycolide) PCL= poly(ε-caprolactone) |
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| 50:50 DL-PLG | 1.34 | 6000 - 8000 | 3 - 10 | 2 - 4x105 |
| 65:35 DL-PLG | 1.30 | 6000 - 8000 | 3 - 10 | 2 - 4x105 |
| 75:25 DL-PLG | 1.30 | 6000 - 8000 | 3 - 10 | 2 - 4x105 |
| 85:15 DL-PLG | 1.27 | 6000 - 8000 | 3 - 10 | 2 - 4x105 |
| DL-PLA | 1.25 | 4000 - 6000 | 3 - 10 | 2 - 4x105 |
| L-PLA | 1.24 | 8000 - 12000 | 5 -10 | 4 - 6x105 |
| PGA | 1.53 | 10000+ | 15 - 20 | 1x106+ |
| PCL | 1.11 | 3000 - 5000 | 300 - 500 | 3 - 5x104 |
| 25:75 DL-PLCL | 1.15 | ~1100 | ~600 | 5x104 - 2x105 |
| 80:20 DL-PLCL | 1.22 | ~750 | ~150 | 6x104 - 2x105 |
