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Biodegradation

DURECT can customize polymers to meet specific degradation requirements. The polymers and copolymers of glycolide, lactide, and ε-caprolactone degrade by simple hydrolysis. When exposed to aqueous media such as buffers or tissue, water is absorbed and reacts with the ester linkages, thus breaking the polymer backbone. One hydroxyl group and one carboxylic acid group forms for each ester linkage that is hydrolyzed. Because the ester linkages are cleaved randomly along the polymer backbone, relatively few water-soluble fragments form initially. Rather, long polymer chains are broken to form shorter ones. As a result, the reduction in molecular weight produces an increase in hydrophilicity but little change initially in physical properties or polymer mass. As degradation proceeds, however, the reduction in molecular weight leads to a reduction in physical properties and the formation of water-soluble fragments. These water-soluble fragments diffuse away from the polymer and are ultimately hydrolyzed to glycolic and lactic acids, which are processed through normal metabolic pathways. The rate of hydrolysis depends on factors such as the size and hydrophilicity of the particular polymer implant, the monomer composition and degree of crystallinity of the polymer, and the pH and temperature of the environment.

Order Polymers

We offer a variety of polymers and sample kits in stock for prompt delivery.

Standard Products

A complete list of Standard Product pharmaceutical grade polymers available from LACTEL.

Custom Polymers

If additional product optimization is required, we can provide developmental input and custom synthesis. A large percentage of our polymer business at DURECT is devoted to the development of polymers with customized characteristics.

Safety Data Sheets

The following Safety Data Sheets are saved in a format that can be viewed and printed from Acrobat Reader.
CONTACT US:

LACTEL Absorbable Polymers

2200 Riverchase Center, Suite 501
Birmingham, AL 35244 USA


Customer Service:


Phone: (877) 705-8072 Fax: (408) 865-1406

E-mail: absorbablescs@durect.com

LACTEL Technical Support:

Phone: (205) 578-5102

E-mail: absorbables@durect.com