Poly(ε-caprolactone) and Poly(DL-lactide-co-ε-caprolactone)

We produce poly(ε-caprolactone), also referred to as PCL, and poly(DL-lactide-co-ε-caprolactone) copolymers, also called DL-PLCLs. Polymers made from caprolactone are currently used in medical applications such as sutures and adhesion barriers. They are popular among researchers for tissue engineering for their relatively long half-life in vivo, degradation time, mechanical strength and elasticity.

Our PCL and DL-PLCL products are offered in various molecular weights. For the copolymers, two different monomer compositions are available. Please refer to the table below.

The LACTEL brand has been a reliable and proven source of these materials for 30 years. Our commitment to quality includes a thorough analysis of each lot of polymer, and every shipment of medical grade polymer includes a Certificate of Analysis (COA). Analyses include:

  • Identification by 1H-NMR and FTIR
  • Inherent viscosity (IV)
  • Monomer ratio
  • Residual monomer levels by 1H-NMR
  • Residual tin (from catalyst)
  • Residual solvents
  • Bioburden (total aerobes, spores, and anaerobes)
  • Pyrogens (LAL)

Other analyses can be provided if desired, including heavy metals, solubility and cloud point in various solvents, DSC, and other compendial tests. We also have considerable expertise in measuring molecular weights using GPC and NMR techniques.

DURECT maintains both Drug and Device Master Files with the FDA. All pharmaceutical grade polymer production is conducted in accordance with the International Pharmaceutical Excipients Council (IPEC) Good Manufacturing Practices Guide for Bulk Pharmaceutical Excipients, which are recognized and published in the United States Pharmacopeia. Polymers are produced in ISO 8 clean rooms with controlled temperature and humidity in our modern, well-equipped production and laboratory facilities in Birmingham, Alabama, USA.


Product No.Chemical NameEnd GroupAbbrevInherent Viscosity (IV) dL/g
Ester Terminated Polymers
B6003-1Poly(ε-caprolactone)EPCL0.65 - 0.85
B6003-2Poly(ε-caprolactone)EPCL1.0 - 1.3
B6015-1*25:75 Poly(DL-lactide-co-ε-caprolactone)E25:75 DL-PLCL0.70 - 0.90
B6016-180:20 Poly(DL-lactide-co-ε-caprolactone)E80:20 DL-PLCL0.70 - 0.90
End GroupE - Ester Terminated
*Not routinely stocked. Please call for quote and availability.

Order Polymers

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We offer a variety of polymers and sample kits in stock for prompt delivery.

Technical Data

Technical Data Image

Data describing characteristics of lactide, glycolide and ε-caprolactone polymers to assist you in selecting the optimal polymer for your program.